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This presentation will take the audience through the emergence of the pediatric HIV/AIDS epidemic beginning in the early 1980’s through the current challenges associated with survival and transition to adult care. Diagnosis, child and parental adjustment, adherence, advance care planning, bereavement, child and parental survival, and professional challenges will be presented via the findings of psychosocial research data and clinical interviews. Material produced during therapeutic sessions will be used to illustrate the changing epidemic. Videotapes illustrating longitudinal developmental considerations will be shared.